1 . Pathological freckles the damage did not increase the number of melanoma cells with DOPA staining freckles of the melanoma cells decreased density than the surrounding normal skin, but can be seen freckles melanocytes than the surrounding Skin melanocytes are large and longer branches with more sudden, staining compared with normal skin deep. With the electron microscope, freckles of the melanoma cells produce large amounts of oval black pigment granules, similar to the black people of the melanocytes, adjacent normal skin a small amount of black pigment granules, melanosomes of light, there are significant differences between the two.
2 . Wood lamp pigment lesions is more evident.
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