women with this disease is partial or complete male hairy type, caused by the androgen. The severity of hirsutism depends on androgen levels and hair follicles of androgen responsiveness. Many causes of this disease, common following:
(1) Polycystic ovary syndrome (po1ycystic ovary syndrome): Also known as Stein-Leventhal syndrome, is more than the most common cause of hirsutism, occur in adolescence, the ovaries produce testosterone increased plasma testosterone, with an increasing. Starting menstruation in patients with normal menstruation after the reduction. Loss of libido, infertility, hirsutism (not very significant.) Bilateral ovarian symmetry increases. 20% of the patients acne .
(2) ovarian tumors (ovariantumors): rare, hirsutism developed rapidly, there masculine. Ovarian androgen secretion of ovarian tumors, including adenoma, male cell tumor, Leyding grain membrane cell tumors and follicular tumors. Tumor occurred in the corpus luteum in pregnant women can also lead to hirsutism.
(3) congenital adrenal hyperplasia (congenital adrenalhyperplasia): an autosomal recessive inheritance of the adrenal genital syndrome (adrenogenital syndrome), 10% of patients in hirsutism after puberty. Since 17 - hydroxyprogesterone 21 - hydroxylation is blocked, ACTH, testosterone and androstenedione levels increased and the formation of low levels of cortisol, while attempting to maintain normal adrenal cortisol secretion, caused by excessive activity of its hairy disease and masculine. How the majority of patients with cystic ovarian disease. 11 - hydroxylase or 33 - hydroxylation of genetic defects in steroid dehydrogenase activity can cause similar symptoms, such as Cushing syndrome and various adrenal tumors.
(4) High prolactin hyperlipidemia (hyperprodactinemia): pituitary adenoma, hypothyroidism, stress, hypothalamic disease, drug (phenothiazine), liver and kidney failure can produce too much prolactin, and its serum levels, hirsutism, and amenorrhea may be associated with galactorrhea syndrome.
(5) acromegaly (acrormegaly): Excessive adrenal and pituitary hormones can increase ovarian androgen production, accompanied by hairy.
(6) idiopathic hirsutism (idiopathic hirsutism): occurs mainly in certain ethnic groups, with a clear tendency of familial disease. Hairy begins in adolescence, after decades of continued development. Patients without ovarian cancer, failed to find endocrine abnormalities, such as prolactin, dehydroepiandrosterone androstane ketones, testosterone, luteinizing hormone, follicle stimulating hormone plasma levels are usually normal, but normal serum levels in patients with follicular androgen on the regulation of susceptibility, which occurred in hairy.
(7) drug-induced hirsutism: If minoxidil, phenytoin, and male hormones can cause hirsutism and virilization.
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